2021 L'Open 35 de Saint-Malo – Singles

Nadia Podoroska was the defending champion but chose not to participate.

Viktorija Golubic won the title, defeating Jasmine Paolini in the final, 6–1, 6–3.

Seeds
• #🇫🇷 Alizé Cornet (first round)

• #🇸🇪 Rebecca Peterson (quarterfinals)

• #🇧🇪 Alison Van Uytvanck (first round)

• # Tamara Zidanšek (second round)

• # Viktorija Golubic (champion)

• # Arantxa Rus (second round)

• #🇷🇸 Nina Stojanović (second round)

• #🇺🇸 Christina McHale (first round)

Seeds
• # Clara Tauson (qualified)

• # 🇧🇬 Viktoriya Tomova (qualified)

• # 🇨🇳 Wang Xiyu (moved to main draw)

• # 🇺🇦 Kateryna Kozlova (moved to main draw)

• # Leonie Küng (first round)

• # 🇯🇵 Kurumi Nara (first round)

• # 🇫🇷 Tessah Andrianjafitrimo (qualified)

• # 🇫🇷 Amandine Hesse (qualifying competition, lucky loser)

Qualifiers
• # Clara Tauson

• # 🇧🇬 Viktoriya Tomova

• # 🇧🇷 Luisa Stefani

• # 🇫🇷 Tessah Andrianjafitrimo

Lucky loser
• # 🇫🇷 Amandine Hesse