2021 LTP Charleston Pro Tennis – Singles

Mayar Sherif was the defending champion but lost to Claire Liu in the second round.

Liu went on to win the title, defeating Madison Brengle in the final, 6–2, 7–6(8–6).

Seeds
• # 🇺🇸 Madison Brengle (final)

• # 🇺🇸 Caty McNally (first round)

• # 🇪🇬 Mayar Sherif (second round)

• # 🇺🇸 Kristie Ahn (first round)

• # 🇷🇴 Irina Bara (second round)

• # 🇲🇽 Renata Zarazúa (quarterfinals)

• # 🇧🇾 Olga Govortsova (quarterfinals)

• # 🇨🇳 Wang Xinyu (first round)