2021 LTP Charleston Pro Tennis II – Singles

Caroline Dolehide was the defending champion, having won the previous edition in 2019, however she chose to participate in qualifying for Wimbledon instead.

Despina Papamichail won the title, defeating Gabriela Cé in the final, 1–6, 6–3, 6–3.

Seeds
• # Conny Perrin (first round)

• # Despina Papamichail (champion)

• # 🇺🇸 Hanna Chang (second round)

• # 🇺🇸 Alycia Parks (second round)

• # 🇯🇵 Kyōka Okamura (first round)

• # 🇧🇷 Gabriela Cé (final)

• # 🇲🇽 Marcela Zacarías (first round)

• # 🇺🇸 Alexa Glatch (quarterfinals)