2021 Ladies Open Lausanne – Singles

Fiona Ferro was the defending champion from 2019, when the event was last held, but lost to Clara Burel in the quarterfinals.

Tamara Zidanšek won her maiden WTA Tour singles title, defeating Burel in the final, 4–6, 7–6(7–5), 6–1.

Seeds
• # Tamara Zidanšek (champion)

• #🇫🇷 Fiona Ferro (quarterfinals)

• # Jil Teichmann (first round)

• #🇮🇹 Camila Giorgi (second round)

• #🇫🇷 Caroline Garcia (semifinals)

• # Arantxa Rus (first round)

• #🇮🇹 Jasmine Paolini (second round)

• #🇷🇺 Anna Blinkova (second round)

Seeds
• # 🇦🇺 Astra Sharma (qualified)

• # 🇮🇹 Lucia Bronzetti (qualified)

• # 🇳🇴 Ulrikke Eikeri (qualified)

• # Valentini Grammatikopoulou (qualified)

Qualifiers
• # 🇦🇺 Astra Sharma

• # 🇮🇹 Lucia Bronzetti

• # 🇳🇴 Ulrikke Eikeri

• # Valentini Grammatikopoulou