2021 Liga 3 Special Region of Yogyakarta

The 2021 Liga 3 Special Region of Yogyakarta (also known as Liga 3 MS Glow For Men PSSI Yogyakarta for sponsorship reason ) was the fourth season of Liga 3 Special Region of Yogyakarta as a qualifying round for the national round of the 2021–22 Liga 3.

Sleman United were the defending champion.

Teams
The league consisted of fifteen teams.

Group A
All matches were held at the Dwi Windu Stadium, Bantul Regency.

Group B
All matches were held at the Kridosono Stadium, Yogyakarta.

Group C
All matches were held at the Tridadi Stadium, Sleman Regency.

Group X
All matches were held at the Kridosono Stadium, Yogyakarta.

Group Y
All matches were held at the Dwi Windu Stadium, Bantul Regency.