2021 Lima Challenger II – Singles

Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.

Nicolás Jarry won the title after defeating Cerúndolo 6–2, 7–5 in the final.

Seeds
• # 🇧🇷 Thiago Monteiro (withdrew)

• # 🇦🇷 Juan Manuel Cerúndolo (final)

• # 🇨🇴 Daniel Elahi Galán (first round)

• # 🇦🇷 Francisco Cerúndolo (withdrew)

• # 🇦🇷 Sebastián Báez (withdrew)

• # 🇧🇷 Thiago Seyboth Wild (second round)

• # 🇧🇴 Hugo Dellien (quarterfinals)

• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇦🇷 Tomás Martín Etcheverry (quarterfinals)

• # Marcelo Tomás Barrios Vera (quarterfinals)