2021 Los Cabos Open – Doubles

Romain Arneodo and Hugo Nys were the reigning champions from when the tournament was last held in 2019, but chose to play in Gstaad instead.

Hans Hach Verdugo and John Isner won the title, defeating Hunter Reese and Sem Verbeek in the final, 5–7, 6–2, [10–4].

Seeds
• # 🇬🇧 Luke Bambridge / 🇬🇧 Ken Skupski (first round)

• # 🇮🇱 Jonathan Erlich / 🇲🇽 Santiago González (quarterfinals)

• # 🇵🇰 Aisam-ul-Haq Qureshi / 🇮🇳 Divij Sharan (first round)

• # 🇦🇺 Matthew Ebden / 🇦🇺 John-Patrick Smith (quarterfinals)