2021 Los Cabos Open – Singles

Diego Schwartzman was the reigning champion from when the tournament was last held in 2019, but chose to compete at the Summer Olympics instead.

Cameron Norrie won his maiden ATP Tour title, defeating Brandon Nakashima in the final, 6–2, 6–2.

Seeds
The top 4 seeds receive a bye into the second round. • # 🇬🇧 Cameron Norrie (champion)

• # 🇺🇸 John Isner (semifinals)

• # 🇺🇸 Taylor Fritz (semifinals)

• # 🇺🇸 Sam Querrey (second round)

• # 🇦🇺 Jordan Thompson (quarterfinals)

• # 🇺🇸 Steve Johnson (quarterfinals)

• # 🇮🇹 Andreas Seppi (first round)

• # 🇺🇸 Mackenzie McDonald (first round)

Seeds
• # 🇺🇸 Ernesto Escobedo (qualified)

• # 🇧🇪 Ruben Bemelmans (qualifying competition)

• # 🇦🇺 Matthew Ebden (qualified)

• # 🇯🇵 Yosuke Watanuki (qualifying competition, retired)

• # 🇨🇴 Nicolás Mejía (qualified)

• # 🇦🇺 John-Patrick Smith (qualifying competition)

• # 🇺🇸 Alex Rybakov (qualifying competition)

• # 🇺🇸 Raymond Sarmiento (first round)

Qualifiers
• # 🇺🇸 Ernesto Escobedo

• # 🇨🇴 Nicolás Mejía

• # 🇦🇺 Matthew Ebden

• # 🇺🇸 Alexander Sarkissian