2021 Louisville Cardinals baseball team

The 2021 Louisville Cardinals baseball team represented the University of Louisville during the 2021 NCAA Division I baseball season. The Cardinals played their home games at Jim Patterson Stadium as a member of the Atlantic Coast Conference. They were led by head coach Dan McDonnell, in his 15th season at Louisville.

Previous season
The 2020 Louisville Cardinals baseball team notched a 13–4 (2–1) regular season record. The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.

2020 MLB Draft
The Cardinals had three players drafted in the 2020 MLB draft.