2021 MUSC Health Women's Open

The second 2021 Charleston Open (branded as the MUSC Health Women's Open for commercial reasons) was a tournament on the 2021 WTA Tour. It was played on outdoor green clay courts in Daniel Island. It was held one day after the 48th edition ended and was a replacement tournament for other tournaments that were not held because of travel restrictions, and organised by Charleston Tennis with a single-year licence in 2021, held at Family Circle Tennis Center from April 12 to 18, 2021.

Singles

 * 🇦🇺 Astra Sharma def. 🇹🇳 Ons Jabeur, 2–6, 7–5, 6–1

Doubles

 * 🇺🇸 Hailey Baptiste / 🇺🇸 Caty McNally def. 🇦🇺 Ellen Perez / 🇦🇺 Storm Sanders, 6–7(4–7), 6–4, [10–6]

Seeds

 * 1 Rankings are as of April 5, 2021

Other entrants
The following players received wildcards into the main draw:
 * 🇨🇿 Linda Fruhvirtová
 * 🇺🇸 Emma Navarro
 * 🇺🇸 CoCo Vandeweghe

The following player received entry as a special exempt:
 * 🇨🇴 Camila Osorio

The following players received entry from the qualifying draw:
 * 🇺🇸 Claire Liu
 * 🇺🇸 Grace Min
 * 🇺🇸 Alycia Parks
 * 🇦🇺 Storm Sanders

Withdrawals

 * Before the tournament
 * 🇺🇸 Amanda Anisimova → replaced by 🇺🇸 Caty McNally
 * 🇷🇴 Irina-Camelia Begu → replaced by 🇨🇳 Wang Yafan
 * 🇷🇺 Anna Blinkova → replaced by 🇷🇺 Liudmila Samsonova
 * 🇺🇸 Danielle Collins → replaced by 🇺🇸 Francesca Di Lorenzo
 * 🇺🇸 Coco Gauff → replaced by 🇧🇬 Viktoriya Tomova
 * 🇺🇸 Madison Keys → replaced by 🇮🇹 Sara Errani
 * 🇨🇿 Barbora Krejčíková → replaced by 🇨🇿 Tereza Martincová
 * 🇺🇸 Ann Li → replaced by 🇲🇪 Danka Kovinić
 * 🇺🇸 Jessica Pegula → replaced by Clara Tauson
 * 🇸🇪 Rebecca Peterson → replaced by 🇺🇸 Christina McHale
 * 🇰🇿 Yulia Putintseva → replaced by 🇲🇽 Renata Zarazúa
 * 🇷🇺 Anastasia Potapova → replaced by Stefanie Vögele
 * 🇩🇪 Laura Siegemund → replaced by 🇺🇸 Kristie Ahn
 * 🇺🇸 Sloane Stephens → replaced by 🇷🇺 Natalia Vikhlyantseva

Retirements

 * 🇫🇷 Alizé Cornet
 * 🇯🇵 Misaki Doi
 * 🇨🇿 Tereza Martincová

Seeds

 * Rankings are as of April 5, 2021.

Other entrants
The following pair received a wildcard into the doubles main draw:
 * 🇺🇸 Sophie Chang / 🇺🇸 Emma Navarro

The following pair received entry into the doubles main draw using a protected ranking:
 * Oksana Kalashnikova / 🇷🇺 Alla Kudryavtseva

The following pair received entry into the doubles main draw as an alternate:
 * 🇨🇿 Linda Fruhvirtová / 🇨🇿 Tereza Martincová

Withdrawals

 * Before the tournament
 * 🇷🇺 Anna Blinkova / 🇨🇿 Lucie Hradecká → replaced by 🇫🇷 Elixane Lechemia / 🇺🇸 Ingrid Neel
 * 🇯🇵 Misaki Doi / 🇯🇵 Nao Hibino → replaced by 🇨🇿 Linda Fruhvirtová / 🇨🇿 Tereza Martincová
 * 🇺🇸 Coco Gauff / 🇺🇸 Caty McNally → replaced by Beatrice Gumulya /  Jessy Rompies
 * 🇯🇵 Makoto Ninomiya / 🇨🇳 Yang Zhaoxuan → replaced by 🇺🇸 Jamie Loeb / 🇳🇿 Erin Routliffe
 * During the tournament
 * 🇨🇿 Linda Fruhvirtová / 🇨🇿 Tereza Martincová

Retirements

 * 🇦🇺 Arina Rodionova / Rosalie van der Hoek