2021 Macha Lake Open – Singles

Barbora Krejčíková was the defending champion, having won the previous edition in 2019, but chose not to participate.

Zheng Qinwen won the title, defeating Aleksandra Krunić in the final, 7–6(7–5), 6–3.

Seeds
• # 🇸🇰 Kristína Kučová (first round)

• # 🇹🇷 Çağla Büyükakçay (first round)

• # 🇺🇸 Allie Kiick (first round, retired)

• # 🇭🇺 Réka Luca Jani (quarterfinals)

• # 🇸🇰 Rebecca Šramková (first round)

• # 🇦🇹 Julia Grabher (second round)

• # Verónica Cepede Royg (first round)

• # 🇷🇴 Gabriela Talabă (second round)