2021 Meerbusch Challenger – Singles

Pedro Sousa was the defending champion but chose not to defend his title.

Marcelo Tomás Barrios Vera won the title after defeating Juan Manuel Cerúndolo 7–6(9–7), 6–3 in the final.

Seeds
• # 🇩🇪 Daniel Altmaier (quarterfinals)

• # 🇧🇦 Damir Džumhur (second round)

• # Botic van de Zandschulp (semifinals)

• # 🇩🇪 Oscar Otte (second round)

• # 🇦🇷 Juan Manuel Cerúndolo (final)

• # 🇨🇿 Tomáš Macháč (first round)

• # 🇸🇰 Alex Molčan (withdrew)

• # 🇮🇳 Sumit Nagal (first round)