2021 Men's Egyptian Squash Open

The Men's 2021 CIB Egyptian Open is the men's edition of the 2021 CIB Egyptian Open, which is a 2021–22 PSA World Tour event. The event will take place in Cairo, Egypt between 10 and 17 September, 2021. The event's main sponsor is the Commercial International Bank of Egypt.

Egypt's Ali Farag defeated fellow countryman Mohamed El Shorbagy in the final, winning the tournament for the second time.

Seeds
• # 🇪🇬 Mohamed El Shorbagy (runner-up)

• # 🇪🇬 Ali Farag (champion)

• # 🇪🇬 Tarek Momen (semi-finals)

• # 🇳🇿 Paul Coll (semi-finals)

• # 🇪🇬 Marwan Elshorbagy (quarter-finals)

• # 🇪🇬 Karim Abdel Gawad (third round)

• # 🇪🇬 Fares Dessouky (second round)

• # 🇪🇬 Mostafa Asal (second round)