2021 Mercer Tennis Classic

The 2021 Mercer Tennis Classic was a professional women's tennis tournament played on outdoor hard courts. It was the ninth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Macon, Georgia, United States between 18 and 24 October 2021.

Seeds

 * 1 Rankings are as of 4 October 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Usue Maitane Arconada
 * 🇺🇸 Hailey Baptiste
 * 🇺🇸 Catherine Harrison
 * 🇺🇸 Emma Navarro

The following player received entry using a protected ranking:
 * 🇦🇺 Priscilla Hon

The following players received entry from the qualifying draw:
 * 🇺🇸 Robin Anderson
 * 🇺🇸 Hanna Chang
 * 🇺🇸 Louisa Chirico
 * 🇺🇸 Victoria Duval
 * 🇺🇸 Allie Kiick
 * 🇺🇸 Danielle Lao
 * 🇺🇸 Whitney Osuigwe
 * 🇺🇸 Alana Smith

Singles

 * 🇺🇸 Madison Brengle def. 🇰🇿 Zarina Diyas, 6–4, 4–6, 6–4

Doubles

 * 🇺🇸 Quinn Gleason / 🇺🇸 Catherine Harrison def. 🇺🇸 Alycia Parks / 🇺🇸 Alana Smith, 6–2, 6–2