2021 Mexican League season

The 2021 Mexican League season was the 96th season in the history of the Mexican League. The league was contested by 18 teams, evenly divided in North and South zones. The season started on 20 May with the series between Sultanes de Monterrey and Acereros de Monclova and ended on 15 September with the last game of the Serie del Rey, where Toros de Tijuana defeated Leones de Yucatán to win the championship.

Two teams joined the league for this season: Mariachis de Guadalajara and El Águila de Veracruz, totalling 18 teams. Veracruz returned to the league after a three year absence, when in 2018 the franchise was sold and moved to Nuevo Laredo.

Starting from this season, there were four rounds of playoffs to define the champion. Previously, the Mexican League had three rounds of playoffs.

No-hitters

 * Dylan Unsworth (VER): On 28 May, Unsworth threw his first no-hitter in the Mexican League by defeating the Diablos Rojos del México 8–0.