2021 Miami Open – Women's doubles

Shuko Aoyama and Ena Shibahara defeated Hayley Carter and Luisa Stefani in the final, 6–2, 7–5, to win the women's doubles tennis title at the 2021 Miami Open. Aoyama and Shibahara's first WTA 1000 victory earned them their third title of the year and made them the first Japanese champions in Miami since Ai Sugiyama in 2008.

Elise Mertens and Aryna Sabalenka were the defending champions from when the tournament was last held in 2019, but the pair lost in the first round to Simona Halep and Angelique Kerber.

Sabalenka, Tímea Babos and Hsieh Su-wei were in contention for the WTA doubles No. 1 ranking at the beginning at the tournament. Hsieh usurped Sabalenka for the top ranking after Sabalenka and Babos lost in the first and second round, respectively.

Seeds
• # 🇧🇪 Elise Mertens / 🇧🇾 Aryna Sabalenka (first round)

• # 🇨🇿 Barbora Krejčíková / 🇨🇿 Kateřina Siniaková (second round)

• # 🇺🇸 Nicole Melichar / Demi Schuurs (first round)

• # 🇭🇺 Tímea Babos / 🇷🇺 Veronika Kudermetova (second round)

• # 🇯🇵 Shuko Aoyama / 🇯🇵 Ena Shibahara (champions)

• # 🇨🇳 Xu Yifan / 🇨🇳 Zhang Shuai (second round)

• # Alexa Guarachi / 🇺🇸 Desirae Krawczyk (first round)

• # 🇺🇸 Hayley Carter / 🇧🇷 Luisa Stefani (final)