2021 Mississippi College Choctaws football team

The 2021 Mississippi College Choctaws football team represented Mississippi College as a member of the Gulf South Conference (GSC) during the 2021 NCAA Division II football season. They were led by eighth-year head coach John Bland. The Choctaws played their home games at Robinson-Hale Stadium in Clinton, Mississippi.

Schedule
Mississippi College announced their 2021 football schedule on August 3, 2021.