2021 Moneta Czech Open – Singles

Kamil Majchrzak was the defending champion but chose not to defend his title.

Federico Coria won the title after defeating Alex Molčan 7–6(7–1), 6–3 in the final.

Seeds
• # 🇪🇸 Pablo Andújar (first round)

• # 🇨🇿 Jiří Veselý (second round)

• # 🇮🇹 Gianluca Mager (semifinals)

• # 🇦🇷 Federico Coria (champion)

• # 🇧🇴 Hugo Dellien (quarterfinals)

• # 🇸🇰 Jozef Kovalík (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (first round, retired)

• # Blaž Rola (quarterfinals)