2021 Monterrey Open – Singles

Leylah Fernandez defeated Viktorija Golubic in the final, 6–1, 6–4 to win the singles tennis title at the 2021 Monterrey Open. Fernandez did not drop a set en route to her first WTA Tour singles title.

Elina Svitolina was the reigning champion, but decided not to participate.

Seeds
• #🇺🇸 Sloane Stephens (first round)

• #🇦🇷 Nadia Podoroska (first round)

• #🇨🇳 Zheng Saisai (quarterfinals)

• #🇨🇿 Marie Bouzková (withdrew)

• #🇬🇧 Heather Watson (first round)

• #🇷🇺 Anna Blinkova (first round)

• #🇪🇸 Sara Sorribes Tormo (semifinals)

• #🇺🇸 Ann Li (semifinals)

• #🇯🇵 Nao Hibino (first round)

Seeds
• # Kaja Juvan (qualified)

• # Viktorija Golubic (qualified)

• # 🇪🇸 Aliona Bolsova (first round)

• # 🇮🇹 Sara Errani (first round)

• # 🇧🇪 Greet Minnen (withdrew)

• # 🇺🇸 Kristie Ahn (first round)

• # 🇪🇬 Mayar Sherif (qualified)

• # 🇩🇪 Anna-Lena Friedsam (first round)

• # 🇵🇱 Katarzyna Kawa (first round)

• # 🇷🇺 Anna Kalinskaya (qualified)

• # 🇨🇳 Wang Xiyu (first round)

• # 🇷🇴 Irina Bara (first round)

Qualifiers
• # Kaja Juvan

• # Viktorija Golubic

• # 🇺🇦 Lesia Tsurenko

• # 🇨🇴 Camila Osorio

• # 🇷🇺 Anna Kalinskaya

• # 🇪🇬 Mayar Sherif

Lucky losers
• # 🇸🇰 Kristína Kučová

• # 🇬🇧 Harriet Dart