2021 Murcia Open

The 2021 Murcia Open was a professional tennis tournament played on clay courts. It was the 2nd edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Murcia, Spain, between 27 September and 3 October 2021.

Seeds

 * 1 Rankings are as of 20 September 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇪🇸 Pablo Llamas Ruiz
 * 🇪🇸 Álvaro López San Martín
 * 🇪🇸 Daniel Rincón

The following players received entry into the singles main draw using protected rankings:
 * 🇧🇪 Joris De Loore
 * 🇧🇪 Jeroen Vanneste

The following players received entry from the qualifying draw:
 * 🇺🇸 Emilio Nava
 * 🇮🇹 Francesco Passaro
 * 🇩🇪 Mats Rosenkranz
 * 🇺🇸 Alex Rybakov

Singles

 * Tallon Griekspoor def. 🇪🇸 Roberto Carballés Baena 3–6, 7–5, 6–3.

Doubles

 * 🇮🇹 Raúl Brancaccio / 🇮🇹 Flavio Cobolli def. 🇪🇸 Alberto Barroso Campos / 🇪🇸 Roberto Carballés Baena 6–3, 7–6(7–4).