2021 Murcia Open – Singles

Roberto Carballés Baena was the defending champion but lost in the final to Tallon Griekspoor.

Griekspoor won the title after defeating Carballés Baena 3–6, 7–5, 6–3 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (final)

• # Tallon Griekspoor (champion)

• # 🇦🇺 Marc Polmans (first round)

• # 🇪🇸 Mario Vilella Martínez (first round)

• # 🇦🇷 Marco Trungelliti (second round, withdrew)

• # 🇮🇳 Ramkumar Ramanathan (first round)

• # 🇸🇰 Filip Horanský (second round)

• # 🇫🇷 Mathias Bourgue (semifinals, retired)