2021 Murray River Open – Singles

The Murray River Open was a new addition to the ATP Tour in 2021.

Dan Evans won his maiden ATP title, defeating Félix Auger-Aliassime in the final, 6–2, 6–3. This was the seventh consecutive final loss of Auger-Aliassime's career.

Seeds
The top eight seeds received a bye into the second round.

Stan Wawrinka (quarterfinals, withdrew) 🇧🇬 Grigor Dimitrov (quarterfinals) 🇨🇦 Félix Auger-Aliassime (final) Borna Ćorić (quarterfinals) 🇳🇴 Casper Ruud (second round) 🇺🇸 Taylor Fritz (third round) 🇫🇷 Ugo Humbert (second round) 🇬🇧 Dan Evans (champion)

🇮🇹 Lorenzo Sonego (first round) 🇫🇷 Adrian Mannarino (second round) Marin Čilić (first round) 🇪🇸 Albert Ramos Viñolas (second round) 🇦🇺 Nick Kyrgios (third round) 🇫🇷 Richard Gasquet (first round) 🇺🇸 Tommy Paul (second round) 🇭🇺 Márton Fucsovics (second round)