2021 Mutua Madrid Open – Women's doubles

Barbora Krejčíková and Kateřina Siniaková defeated Gabriela Dabrowski and Demi Schuurs in the final, 6–4, 6–3 to win the women's doubles tennis title at the 2021 Madrid Open. It marked the duo's seventh career WTA Tour doubles title together, as well as Krejčíková's eighth individual doubles title and Siniaková's 10th.

Hsieh Su-wei and Barbora Strýcová were the reigning champions from when the tournament was last held in 2019, but Strýcová did not return to compete due to her pregnancy. Hsieh partnered Elise Mertens; they lost in the second round to Jeļena Ostapenko and Anastasia Pavlyuchenkova. Despite the loss, Mertens usurped Hsieh for the WTA No. 1 doubles ranking.

Seeds
• # Hsieh Su-wei / 🇧🇪 Elise Mertens (second round)

• # 🇨🇿 Barbora Krejčíková / 🇨🇿 Kateřina Siniaková (champions)

• # 🇨🇦 Gabriela Dabrowski / Demi Schuurs (final)

• # 🇯🇵 Shuko Aoyama / 🇯🇵 Ena Shibahara (first round)

• # Alexa Guarachi / 🇺🇸 Desirae Krawczyk (second round)

• # Chan Hao-ching /  Latisha Chan (first round)

• # 🇨🇳 Xu Yifan / 🇨🇳 Zhang Shuai (quarterfinals)

• # 🇺🇸 Hayley Carter / 🇧🇷 Luisa Stefani (first round)

Seeds

 * Rankings are as of April 26, 2021.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇪🇸 Paula Badosa / 🇪🇸 Sara Sorribes Tormo
 * 🇪🇸 Aliona Bolsova / 🇲🇪 Danka Kovinić

The following pair received entry into the doubles main draw using a protected ranking:
 * Oksana Kalashnikova / 🇷🇺 Alla Kudryavtseva
 * 🇯🇵 Makoto Ninomiya / 🇰🇿 Yaroslava Shvedova
 * 🇷🇺 Elena Vesnina / 🇷🇺 Vera Zvonareva

The following pair received entry into the doubles draw as an alternate:
 * 🇵🇱 Paula Kania-Choduń / 🇵🇱 Katarzyna Piter
 * Petra Martić / 🇺🇸 Shelby Rogers

Withdrawals

 * Before the tournament
 * 🇭🇺 Tímea Babos / 🇷🇺 Veronika Kudermetova → replaced by 🇷🇺 Veronika Kudermetova / 🇷🇺 Anastasia Potapova
 * 🇦🇺 Ashleigh Barty / 🇺🇸 Jennifer Brady → replaced by 🇯🇵 Nao Hibino / 🇨🇿 Renata Voráčová
 * 🇪🇸 Aliona Bolsova / 🇲🇪 Danka Kovinić → replaced by 🇵🇱 Paula Kania-Choduń / 🇵🇱 Katarzyna Piter
 * 🇷🇺 Anna Kalinskaya / 🇸🇰 Viktória Kužmová → replaced by 🇷🇺 Ekaterina Alexandrova / 🇨🇳 Yang Zhaoxuan
 * 🇺🇸 Asia Muhammad / 🇺🇸 Jessica Pegula → replaced by 🇺🇸 Kaitlyn Christian / 🇺🇸 Sabrina Santamaria
 * 🇰🇿 Elena Rybakina / Maria Sakkari → replaced by  Petra Martić / 🇺🇸 Shelby Rogers


 * During the tournament
 * 🇧🇾 Victoria Azarenka / 🇹🇳 Ons Jabeur