2021 NBL–Pilipinas Chairman's Cup

The 2021 NBL–Pilipinas Chairman's Cup, also known as the 2021 Chooks-to-Go NBL Chairman's Cup for sponsorship reasons, was the fourth conference of NBL–Pilipinas. It was also the league's first conference under professional status as recognized by the Games and Amusement Board.

The inaugural pro league season opened on July 18, 2021 with 11 teams. However the league was suspended in July 30, 2021 due to stricter COVID-19 community quarantine imposed in Greater Manila. The NBL resumed play on September 18, 2021.

The Pampanga Delta clinched the 2021 NBL title at La Union Paower's expense.

Venue
Due to the COVID-19 pandemic in Metro Manila, the season was played in Bren Z. Guiao Convention Center in San Fernando, Pampanga in a closed-circuit format behind closed doors.

Quarterfinals
The higher-seeded team has a twice-to-beat advantage. The lower-seeded team had to win over the other twice in order to advance to the semifinals. The higher seeded team only had to win once.