2021 NCAA Division II men's basketball tournament

The 2021 NCAA Division II men's basketball tournament was an annual single-elimination tournament to determine the national champion of men's NCAA Division II college basketball in the United States. The championship games were held March 24–27, 2021 at the Ford Center in Evansville, Indiana, without fans.

Defending champions Northwest Missouri State defeated West Texas A&M in the championship game, 80–54, to claim the Bearcats' second consecutive and third overall Division II national title.

Biola, Flagler, Fresno Pacific, Lee, Malone, Northwest Nazarene, Nyack, Oklahoma Baptist, and Southern Arkansas qualified for the Division II tournament for the first time.

Qualification
A total of 48 bids were available for the tournament: 16 automatic (awarded to the champions of the sixteen Division II conferences that crowned a basketball champion after the end of the regular season) and 32 at-large.

The field size was temporarily reduced for just the 2021 championship to account for teams and conferences that chose to not compete during the 2020–21 season due to the COVID-19 pandemic.

Teams from four conferences (CCAA, CIAA, Northeast-10, and Sunshine State) did not participate in the regular season or the tournament.

The remaining bids were allocated evenly among the eight NCAA-designated regions (Atlantic, Central, East, Midwest, South, South Central, Southeast, and West). Some conferences, however, were shifted from their traditional region to ensure an even distribution of teams across all eight regions. Each region consisted of two automatic qualifiers (the teams who won their respective conference tournaments) and at-large bids.

Automatic bids (16)
* Conference moved out of its usual region.

Atlantic Regional

 * Site: West Liberty, West Virginia (West Liberty)

Central Regional

 * Site: Aberdeen, South Dakota (Northern State)

East Regional

 * Site: Albany, New York (Saint Rose)

Midwest Regional

 * Site: Evansville, Indiana (Southern Indiana)

South Regional

 * Site: Valdosta, Georgia (Valdosta State)

Southeast Regional

 * Site: Harrogate, Tennessee (Lincoln Memorial)

South Central Regional

 * Site: Lubbock, Texas (Lubbock Christian)

West Regional

 * Site: Golden, Colorado (Colorado Mines)

Elite Eight

 * Site: Ford Center, Evansville, Indiana