2021 North Carolina Central Eagles football team

The 2021 North Carolina Central Eagles football team represented North Carolina Central University as a member of the Mid-Eastern Athletic Conference (MEAC) during the 2021 NCAA Division I FCS football season. Led by second-year head coach Trei Oliver, the Eagles compiled an overall record of 6–5 with a mark of 4–1, placing second in the MEAC. North Carolina Central played home games at O'Kelly–Riddick Stadium in Durham, North Carolina.