2021 North Dakota State Bison football team

The 2021 North Dakota State Bison football team represented the North Dakota State University in the 2021 NCAA Division I FCS football season. The Bison competed as members of the Missouri Valley Football Conference and were led by third-year head coach Matt Entz. They played their home games at Fargodome in Fargo, North Dakota.

The Bison finished their regular season with a 10–1 record (7–1 in conference), losing only to South Dakota State. They were seeded second in the FCS postseason tournament and received a first-round bye; they then defeated Southern Illinois, East Tennessee State, and James Madison to reach the championship game. The Bison completed their season by defeating Montana State on January 8 in Frisco, Texas, to capture the program's ninth FCS title in 11 seasons.

2022 NFL Draft
The following Bison players were selected in the 2022 NFL Draft.