2021 Nottingham Open – Women's singles

Johanna Konta defeated Zhang Shuai in the final, 6–2, 6–1 to win the women's singles tennis title at the 2021 Nottingham Open. The win earned Konta her fourth career singles title, her first since 2017, and made her the first British player to win a WTA Tour singles title on home soil since Sue Barker in 1981. This would also be Konta's final title before she announced her retirement in December 2021 due to a long-term knee injury.

Caroline Garcia was the reigning champion from when the event was last held in 2019, but she did not return to compete.

This tournament marked the WTA Tour main draw debut of future US Open champion Emma Raducanu; she lost in the first round to Harriet Dart.

Seeds
All seeds received byes into the second round. • #🇬🇧 Johanna Konta (champion)

• #🇺🇸 Alison Riske (third round)

• # Donna Vekić (third round)

• #🇨🇳 Zhang Shuai (final)

• #🇺🇸 Danielle Collins (withdrew)

• #🇨🇿 Marie Bouzková (second round)

• #🇫🇷 Kristina Mladenovic (quarterfinals)

• #🇧🇪 Alison Van Uytvanck (quarterfinals)

• #🇬🇧 Heather Watson (third round)

• # Viktorija Golubic (third round)

• #🇮🇹 Camila Giorgi (withdrew)

• #🇯🇵 Nao Hibino (second round)

• #🇺🇸 Madison Brengle (second round)

• #🇺🇸 Lauren Davis (semifinals)

• #🇷🇸 Nina Stojanović (semifinals)

• #🇰🇿 Zarina Diyas (third round)

• #🇨🇿 Tereza Martincová (quarterfinals)

• #🇺🇸 Christina McHale (second round)

Seeds
• # 🇺🇦 Kateryna Kozlova (qualified)

• # 🇮🇹 Giulia Gatto-Monticone (moved to main draw)

• # 🇷🇺 Anastasia Gasanova (moved to main draw)

• # Lesley Pattinama Kerkhove (qualified)

• # 🇮🇳 Ankita Raina (qualified)

• # 🇪🇸 Georgina García Pérez (qualifying competition; Lucky loser)

• # 🇷🇺 Marina Melnikova (qualifying competition; Lucky loser)

• # 🇮🇹 Martina Di Giuseppe (qualifying competition; Lucky loser)

Qualifiers
• # 🇺🇦 Kateryna Kozlova

• # 🇬🇧 Eden Silva

• # 🇬🇧 Sarah Beth Grey

• # Lesley Pattinama Kerkhove

• # 🇮🇳 Ankita Raina

• # 🇺🇸 Katie Volynets

• # 🇺🇸 CoCo Vandeweghe

• # 🇬🇧 Tara Moore

Lucky losers
• # 🇮🇹 Martina Di Giuseppe

• # 🇷🇺 Marina Melnikova

• # 🇪🇸 Georgina García Pérez