2021 OL Reign season

The 2021 OL Reign season was the team's ninth season of play and their ninth season in the National Women's Soccer League, the top division of women's soccer in the United States.

On July 2, 2021, head coach Farid Benstiti resigned and was replaced by assistant coach Sam Laity in an interim capacity. Benstiti finished with a 2–1–4 record in the regular season.

On July 15, 2021, the team announced that Laura Harvey would return as head coach after the Tokyo Olympics, where she was serving as an assistant coach for the United States women's national team. Harvey officially assumed head coaching duties on August 9, 2021.

Competitions
All times are in PT unless otherwise noted.

Appearances and goals

 * colspan="12" |Goalkeepers:
 * colspan="12" |Goalkeepers:


 * colspan="12" |Defenders:
 * colspan="12" |Defenders:


 * colspan="12" |Midfielders:
 * colspan="12" |Midfielders:


 * colspan="12" |Forwards:
 * colspan="12" |Forwards:


 * colspan="12" |Players who left the team during the season:
 * colspan="12" |Players who left the team during the season:


 * colspan="12" |Own goals for:
 * colspan="12" |Own goals for:


 * colspan="12" |Others for:
 * colspan="12" |Others for:



Transfers
For incoming transfers, dates listed are when OL Reign officially signed the players to the roster. Transactions where only the rights to the players are acquired (e.g., draft picks) are not listed. For outgoing transfers, dates listed are when OL Reign officially removed the players from its roster, not when they signed with another team. If a player later signed with another team, her new team will be noted, but the date listed here remains the one when she was officially removed from the OL Reign roster.

Draft picks
Draft picks are not automatically signed to the team roster. Only those who are signed to a contract will be listed as incoming transfers. Only trades involving draft picks and executed on the day of the 2021 NWSL Draft will be listed in the notes.

NWSL annual awards

 * Coach of the Year: 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Laura Harvey
 * Most Valuable Player: 🏴󠁧󠁢󠁷󠁬󠁳󠁿 Jess Fishlock
 * Defender of the Year: 🇺🇸 Alana Cook (finalist)
 * Best XI: 🇺🇸 Alana Cook, 🏴󠁧󠁢󠁷󠁬󠁳󠁿 Jess Fishlock, 🇫🇷 Eugénie Le Sommer
 * Second XI: 🇺🇸 Bethany Balcer, 🇺🇸 Sofia Huerta

Team awards

 * Announced on November 23, 2021.


 * Most Valuable Player: 🏴󠁧󠁢󠁷󠁬󠁳󠁿 Jess Fishlock
 * Golden Boot: 🇺🇸 Bethany Balcer
 * Young Player of the Year: 🇺🇸 Alana Cook
 * Community Champion: 🇺🇸 Dani Weatherholt