2021 Oklahoma State Cowboys baseball team

The 2021 Oklahoma State Cowboys baseball team will represent Oklahoma State University during the 2021 NCAA Division I baseball season. The Cowboys play their home games at O'Brate Stadium as a member of the Big 12 Conference. They are led by head coach Josh Holliday, in his 9th season at Oklahoma State.

This will be the program's first season at O'Brate Stadium, after the 2020 season was canceled prior to the opening game at the ballpark due to the COVID-19 pandemic.

Previous season
The 2020 Oklahoma State Cowboys baseball team notched a 13–5 record in February and early March; however, the remainder of the season was abruptly halted on March 13, 2020, when the Big 12 Conference canceled the remainder of the athletics season due to the Coronavirus pandemic.

Schedule and results
! style="background:#FF6600;color:white;"| Regular season (32–16–1)
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! style="background:#FF6600;color:white;"| Postseason (4–3–0)
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 * Legend:      = Win       = Loss       = Tie       = Canceled      Bold = Oklahoma State team member
 * "*" indicates a non-conference game. "#" represents ranking. All rankings from D1Baseball on the date of the contest. "" represents postseason seeding in the Big 12 Tournament or NCAA Regional, respectively.
 * "*" indicates a non-conference game. "#" represents ranking. All rankings from D1Baseball on the date of the contest. "" represents postseason seeding in the Big 12 Tournament or NCAA Regional, respectively.