2021 Open Bogotá – Singles

Marcelo Arévalo was the defending champion but chose not to defend his title.

Gerald Melzer won the title after defeating Facundo Mena 6–2, 3–6, 7–6(7–5) in the final.

Seeds
• # 🇨🇴 Daniel Elahi Galán (second round)

• # 🇩🇪 Daniel Altmaier (second round)

• # 🇨🇿 Vít Kopřiva (first round)

• # Nicolás Jarry (first round)

• # 🇦🇷 Facundo Mena (final)

• # Jesper de Jong (semifinals)

• # 🇺🇸 Ulises Blanch (first round)

• # 🇹🇳 Malek Jaziri (first round)