2021 Open Città della Disfida – Doubles

Denys Molchanov and Igor Zelenay were the defending champions but chose not to defend their title.

Marco Bortolotti and Cristian Rodríguez won the title after defeating Gijs Brouwer and Jelle Sels 6–2, 6–4 in the final.

Seeds
• # 🇻🇪 Luis David Martínez / 🇮🇹 Andrea Vavassori (semifinals)

• # 🇫🇷 Sadio Doumbia / 🇫🇷 Fabien Reboul (quarterfinals)

• # 🇨🇴 Nicolás Barrientos / 🇮🇹 Julian Ocleppo (quarterfinals)

• # 🇺🇸 James Cerretani / 🇺🇸 Junior Alexander Ore (first round)