2021 Open Ciudad de Valencia – Singles

Varvara Gracheva was the defending champion but chose to participate at the 2021 J&T Banka Ostrava Open instead.

Arantxa Rus won the title, defeating Mihaela Buzărnescu in the final, 6–4, 7–6(7–3).

Seeds
• # Arantxa Rus (champion)

• # 🇮🇹 Martina Trevisan (withdrew)

• # 🇮🇹 Sara Errani (withdrew)

• # 🇷🇴 Irina Bara (quarterfinals)

• # 🇸🇰 Kristína Kučová (first round)

• # 🇭🇺 Dalma Gálfi (first round, retired)

• # Ekaterine Gorgodze (first round)

• # 🇬🇧 Francesca Jones (quarterfinals)

• # 🇪🇸 Aliona Bolsova (semifinals)