2021 Open International de Tennis de Roanne – Singles

This was the first edition of the tournament.

Hugo Grenier won the title after defeating Hiroki Moriya 6–2, 6–3 in the final.

Seeds
• # 🇫🇷 Benoît Paire (first round)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇨🇿 Jiří Veselý (first round, retired)

• # 🇸🇪 Mikael Ymer (second round)

• # Henri Laaksonen (first round)

• # 🇦🇹 Dennis Novak (withdrew)

• # 🇲🇩 Radu Albot (quarterfinals)

• # 🇫🇷 Antoine Hoang (first round)

• # 🇫🇷 Hugo Grenier (champion)