2021 Open Montpellier Méditerranée Métropole Hérault – Singles

Varvara Gracheva was the defending champion but chose to compete at Wimbledon instead.

Anhelina Kalinina won the title, defeating Mayar Sherif in the final, 6–2, 6–3.

Seeds
• # 🇫🇷 Océane Dodin (quarterfinals)

• # 🇪🇬 Mayar Sherif (final)

• # 🇺🇦 Anhelina Kalinina (champion)

• # 🇫🇷 Harmony Tan (second round, retired)

• # 🇦🇺 Maddison Inglis (second round)

• # 🇺🇸 Francesca Di Lorenzo (first round)

• # 🇪🇸 Cristina Bucșa (semifinals)

• # 🇺🇸 Grace Min (first round)