2021 Open d'Orléans – Singles

Mikael Ymer was the defending champion but chose not to defend his title.

Henri Laaksonen won the title after defeating Dennis Novak 6–1, 2–6, 6–2 in the final.

Seeds
• # 🇫🇷 Ugo Humbert (first round)

• # 🇫🇷 Benjamin Bonzi (second round)

• # 🇫🇷 Arthur Rinderknech (second round)

• # 🇫🇷 Richard Gasquet (quarterfinals)

• # 🇨🇿 Jiří Veselý (semifinals)

• # 🇫🇷 Corentin Moutet (semifinals)

• # 🇫🇷 Gilles Simon (first round)

• # 🇫🇷 Pierre-Hugues Herbert (second round)