2021 Open de Limoges – Singles

Ekaterina Alexandrova was the defending champion, but chose not to participate in 2021.

Alison Van Uytvanck won the title, defeating Ana Bogdan in the final, 6–2, 7–5.

Seeds
• # 🇨🇳 Zhang Shuai (first round)

• # 🇧🇪 Alison Van Uytvanck (champion)

• # 🇫🇷 Caroline Garcia (quarterfinals)

• # 🇧🇪 Greet Minnen (quarterfinals)

• # 🇷🇺 Varvara Gracheva (semifinals)

• # 🇷🇺 Vera Zvonareva (semifinals)

• # 🇫🇷 Kristina Mladenovic (quarterfinals)

• # 🇷🇴 Ana Bogdan (final)

Seeds
• # 🇫🇷 Elsa Jacquemot (qualified)

• # 🇷🇴 Andreea Roșca (qualified)

• # 🇫🇷 Léolia Jeanjean (qualified)

• # 🇫🇷 Marine Partaud (qualified)

• # 🇫🇷 Estelle Cascino (qualifying competition)

• # 🇫🇷 Margaux Rouvroy (qualifying competition)

• # 🇩🇪 Jasmin Jebawy (qualifying competition)

• # 🇫🇷 Evita Ramirez (qualifying competition)

Qualifiers
• # 🇫🇷 Elsa Jacquemot

• # 🇷🇴 Andreea Roșca

• # 🇫🇷 Léolia Jeanjean

• # 🇫🇷 Marine Partaud