2021 Open de Tenis Ciudad de Pozoblanco – Singles

Roberto Bautista Agut was the defending champion but chose not to defend his title.

Altuğ Çelikbilek won the title after defeating Cem İlkel 6–1, 6–7(2–7), 6–3 in the final.

Seeds
• # 🇫🇷 Benjamin Bonzi (second round)

• # 🇫🇷 Grégoire Barrère (semifinals, retired)

• # 🇹🇷 Altuğ Çelikbilek (champion)

• # 🇹🇷 Cem İlkel (final)

• # 🇫🇷 Maxime Janvier (second round)

• # Borna Gojo (first round)

• # 🇩🇪 Yannick Maden (first round)

• # 🇪🇸 Nicola Kuhn (first round, retired)