2021 Open du Pays d'Aix – Singles

Oscar Otte was the defending champion but retired in the quarterfinals to Elias Ymer.

Carlos Taberner won the title after defeating Manuel Guinard 6–2, 6–2 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (second round)

• # 🇪🇸 Fernando Verdasco (first round)

• # 🇦🇷 Facundo Bagnis (second round)

• # 🇦🇷 Francisco Cerúndolo (second round)

• # 🇵🇪 Juan Pablo Varillas (second round)

• # 🇪🇸 Carlos Taberner (champion)

• # 🇫🇷 Hugo Gaston (second round)

• # 🇮🇳 Sumit Nagal (first round)