2021 Oregon Ducks football team

The 2021 Oregon Ducks football team represented the University of Oregon during the 2021 NCAA Division I FBS football season. The team was led by fourth-year head coach Mario Cristobal, who left the program to take the head coaching job at Miami in early December. The Ducks played their home games at Autzen Stadium in Eugene, Oregon, and competed as members of the North Division of the Pac-12 Conference.

At No. 3 Ohio State
First win against Ohio State (0–9 previously).