2021 Orlando Open – Doubles

Andrey Golubev and Aleksandr Nedovyesov were the defending champions but chose not to defend their title.

Mitchell Krueger and Jack Sock won the title after defeating Christian Harrison and Dennis Novikov 4–6, 7–5, [13–11] in the final.

Seeds
• # 🇲🇽 Miguel Ángel Reyes-Varela / 🇧🇷 Fernando Romboli (first round)

• # 🇺🇸 Evan King / 🇺🇸 Hunter Reese (first round)

• # 🇺🇸 Nathan Pasha / 🇺🇸 Max Schnur (first round)

• # 🇮🇳 Sriram Balaji / 🇮🇳 Jeevan Nedunchezhiyan (first round)