2021 Orlando Open II – Singles

Jenson Brooksby was the defending champion but withdrew from the quarterfinals.

Christopher Eubanks won the title after defeating Nicolás Mejía 2–6, 7–6(7–3), 6–4 in the final.

Seeds
• # 🇯🇵 Yasutaka Uchiyama (first round)

• # Jason Jung (first round)

• # 🇺🇸 Jenson Brooksby (quarterfinals, withdrew)

• # 🇮🇹 Paolo Lorenzi (first round)

• # 🇪🇨 Emilio Gómez (quarterfinals)

• # 🇺🇸 Ernesto Escobedo (first round)

• # 🇦🇷 Guido Andreozzi (second round)

• # 🇺🇸 Mitchell Krueger (second round)