2021 Pilipinas VisMin Super Cup 2nd Conference

The Pilipinas VisMin Super Cup 2nd Conference, was the second season of the Pilipinas VisMin Super Cup.

The tournament featured seven teams that are all based in Mindanao, lacking the presence of any Visayas-based teams. Hence, the tournament is also referred to as the Mindanao Challenge.

The Zamboanga Sibugay Warriors were the champions of the conference, after defeating the Kapatagan Buffalo Braves in the Finals.

Roster regulations
Each team should have no more than six players from Luzon in their roster. In each quarter,teams could field a maximum of two players from Luzon, two from VisMin and one homegrown player per quarter.

Playoffs
Like in the previous conference, every team qualified for the playoffs. The first-seeded team directly qualified to the Semifinals, while teams ranked second through fourth were given twice-to-beat advantage in the Quarterfinals.