2021 Portugal Ladies Open

The 2021 Portugal Ladies Open was a professional women's tennis tournament played on outdoor hard courts. It was the second edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Caldas da Rainha, Portugal between 13 and 19 September 2021.

Seeds

 * 1 Rankings are as of 30 August 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * Francisca Jorge
 * Inês Murta
 * Sara Lança
 * 🇮🇹 Dalila Spiteri

The following player received entry using a junior exempt:
 * 🇺🇦 Daria Snigur

The following player received entry using a special exempt:
 * 🇫🇮 Anastasia Kulikova

The following players received entry from the qualifying draw:
 * 🇷🇴 Elena Bogdan
 * 🇫🇷 Salma Djoubri
 * 🇵🇱 Weronika Falkowska
 * 🇦🇺 Olivia Gadecki
 * 🇷🇴 Ioana Loredana Roșca
 * 🇩🇪 Sarah-Rebecca Sekulic
 * 🇨🇾 Raluca Șerban
 * 🇬🇧 Eden Silva

Singles

 * 🇨🇳 Zheng Saisai def. 🇫🇷 Harmony Tan, 6–4, 3–6, 6–3

Doubles

 * 🇯🇵 Momoko Kobori / 🇯🇵 Hiroko Kuwata def. 🇬🇧 Alicia Barnett / 🇬🇧 Olivia Nicholls, 7–6(7–5), 7–6(7–2)