2021 Potchefstroom Open – Singles

This was the second edition of the tournament. There was no defending champion as the tournament was canceled at the quarterfinals stage due to the COVID-19 pandemic.

Benjamin Bonzi won the title after defeating Liam Broady 7–5, 6–4 in the final.

Seeds
• # 🇮🇳 Prajnesh Gunneswaran (first round)

• # 🇫🇷 Benjamin Bonzi (champion)

• # Marc-Andrea Hüsler (first round)

• # 🇬🇧 Jay Clarke (first round)

• # 🇨🇦 Brayden Schnur (first round)

• # 🇹🇷 Cem İlkel (semifinals)

• # 🇨🇦 Peter Polansky (quarterfinals)

• # 🇩🇴 Roberto Cid Subervi (first round)