2021 Prague Open

The 2021 Prague Open (branded as the 2021 Livesport Prague Open for sponsorship reasons) was a professional women's tennis tournament played on outdoor hard courts at the TK Sparta Prague. It was the 12th (WTA and non-WTA) edition of the tournament which was part of the 2021 WTA Tour, and of the 250 series of tournaments. It took place in Prague, Czech Republic between 12 and 18 July 2021. This was the first edition of the tournament held on outdoor hard courts, as opposed to clay courts in previous editions.

Singles

 * 🇨🇿 Barbora Krejčíková defeated 🇨🇿 Tereza Martincová, 6–2, 6–0.

This was Krejčíková's third WTA singles title of the year.

Doubles

 * 🇨🇿 Marie Bouzková / 🇨🇿 Lucie Hradecká defeated 🇸🇰 Viktória Kužmová / 🇷🇸 Nina Stojanović, 7–6(7–3), 6–4.

Seeds

 * Rankings are as of June 28, 2021

Other entrants
The following players received wildcards into the singles main draw:
 * 🇨🇿 Lucie Havlíčková
 * 🇸🇰 Viktória Kužmová
 * 🇦🇺 Samantha Stosur

The following players received entry using protected rankings:
 * 🇷🇺 Vitalia Diatchenko
 * 🇬🇧 Samantha Murray Sharan
 * 🇨🇿 Tereza Smitková

The following player received entry as a special exempt:
 * 🇷🇴 Elena-Gabriela Ruse

The following players received entry from the qualifying draw:
 * 🇬🇧 Naiktha Bains
 * 🇬🇧 Jodie Burrage
 * 🇺🇸 Asia Muhammad
 * 🇵🇱 Urszula Radwańska
 * 🇧🇬 Isabella Shinikova
 * 🇸🇰 Rebecca Šramková

The following players received entry as lucky losers:
 * 🇷🇺 Anastasia Gasanova
 * Liang En-shuo
 * Conny Perrin

Withdrawals

 * Before the tournament
 * Belinda Bencic → replaced by 🇦🇺 Maddison Inglis
 * 🇫🇷 Océane Dodin → replaced by 🇬🇧 Samantha Murray Sharan
 * Hsieh Su-wei → replaced by Conny Perrin
 * 🇹🇳 Ons Jabeur → replaced by Leonie Küng
 * 🇷🇺 Daria Kasatkina → replaced by 🇨🇳 Wang Xinyu
 * 🇺🇸 Claire Liu → replaced by 🇨🇿 Tereza Smitková
 * 🇧🇬 Tsvetana Pironkova → replaced by 🇺🇸 Grace Min
 * 🇷🇴 Elena-Gabriela Ruse → replaced by 🇷🇺 Anastasia Gasanova
 * Clara Tauson → replaced by 🇪🇸 Nuria Párrizas Díaz
 * 🇦🇺 Ajla Tomljanović → replaced by 🇦🇺 Lizette Cabrera
 * 🇨🇿 Markéta Vondroušová → replaced by Liang En-shuo
 * 🇬🇧 Heather Watson → replaced by 🇮🇹 Giulia Gatto-Monticone
 * 🇷🇺 Vera Zvonareva → replaced by 🇦🇺 Storm Sanders

Seeds

 * 1 Rankings are as of June 28, 2021

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇨🇿 Lucie Havlíčková / 🇨🇿 Miriam Kolodziejová
 * 🇨🇿 Linda Klimovičová / 🇨🇿 Barbora Palicová

Withdrawals

 * Before the tournament
 * 🇷🇺 Anastasia Gasanova / 🇷🇸 Natalija Kostić → replaced by 🇷🇺 Anastasia Gasanova / 🇧🇬 Isabella Shinikova
 * 🇦🇺 Ellen Perez / 🇦🇺 Samantha Stosur → replaced by 🇬🇧 Jodie Burrage / 🇦🇺 Samantha Stosur
 * 🇮🇳 Ankita Raina / Rosalie van der Hoek → replaced by  Conny Perrin /  Rosalie van der Hoek

Retirements

 * Conny Perrin / Rosalie van der Hoek