2021 Prague Open – Doubles

Lucie Hradecká and Kristýna Plíšková were the defending champions, however Plíšková chose not to participate.

Hradecká played alongside Marie Bouzková and successfully defended her title, defeating Viktória Kužmová and Nina Stojanović in the final, 7–6(7–3), 6–4.

Seeds
• # 🇸🇰 Viktória Kužmová / 🇷🇸 Nina Stojanović (final)

• # 🇺🇸 Asia Muhammad / 🇦🇺 Storm Sanders (semifinals)

• # 🇨🇿 Marie Bouzková / 🇨🇿 Lucie Hradecká (champions)

• # Conny Perrin / Rosalie van der Hoek (quarterfinals, retired)