2021 Prairie View A&M Panthers football team

The 2021 Prairie View A&M Panthers football team represented Prairie View A&M University in the 2021 NCAA Division I FCS football season. The Panthers played their home games at Panther Stadium at Blackshear Field in Prairie View, Texas, and competed in the West Division of the Southwestern Athletic Conference (SWAC). They were led by fourth-year head coach Eric Dooley.