2021 President's Cup – Women's singles

Marie Bouzková was the defending champion, having won the previous edition in 2019, however she chose to participate in Prague instead.

Mariam Bolkvadze won the title, defeating Valeria Savinykh in the final, 4–6, 6–3, 6–2.

Seeds
• # Mariam Bolkvadze (champion)

• # 🇷🇺 Valeria Savinykh (final)

• # 🇺🇦 Daria Snigur (second round)

• # 🇧🇾 Yuliya Hatouka (semifinals)

• # 🇧🇷 Laura Pigossi (first round)

• # 🇷🇺 Sofya Lansere (first round)

• # 🇹🇭 Peangtarn Plipuech (second round)

• # 🇧🇾 Anna Kubareva (quarterfinals)