2021 Prince Takamado U-18 Premier League

The 2021 Prince Takamado JFA U-18 Football Premier League (高円宮杯 JFA U-18サッカープレミアリーグ 2021) was the 32nd season of the main competition for under-18 teams in Japan, the 11st after rebranding the competition to the current "Premier League" format, and the last season with 20 clubs participating in the league. It returned after a one-year absence, since the 2020 tournament was cancelled due to COVID-19.

Aomori Yamada High School won the Premier League East, and Sanfrecce Hiroshima won the Premier League West. By default, both group winners would make the final, but it ended up cancelled due to COVID-19 precautions.

League table
The teams were ranked by their points-per-game ratio, as many matches could not be played due to issues related to COVID-19.

Promotion/relegation play-offs
Only for this edition, there were six direct promotions from the Prince Leagues while only two teams got relegated, to accommodate the transition from 20 to 24 teams, that started in the following season.

Qualified to the stage were the 18 (instead of the usual 16) top-ranked teams of the nine Prince League divisions. They were divided into six blocks, with their respective block winners, highlighted in bold qualifying for next season's Premier League.